Scientists understand why antibiotics do not always treat tuberculosis
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Causes tuberculosis bacteria show partial resistance to modern antibiotics. This is founded a team of scientists from the Center for Medical Research at the University of George. Hopkins identified the reason why some anti-TB drugs are clinically effective than others. Detailed results of the study will be published in PNAS. Briefly about the study, reported EurekAlert.
In particular, Biophysics found that bacteria, provoking the development of tuberculosis exhibit fluoroquinolone antibiotic resistance due to their unbalanced composition.
To determine the degree of effectiveness of antibiotics, researchers used the method of X-ray crystallography. Thus, it was reconstituted detailed three-dimensional model of the interaction of bacteria gyrase with five different drugs.
As a result, it was found that the two fluoroquinolones affect bacterial gyrase section, however, on a section of one of the members of the antibiotic against the protein components of at the same time reduces the efficiency of the drug for its properties.
Researchers found that in Europe, there was tuberculosis
It should be noted that fluoroquinolone 8-methyl-moksifloksasin has the most pronounced effect on tuberculosis pathogens, as compared with the other groups of antibiotics.
According to one of the study’s authors, James Berger, studies show that when you create drugs against tuberculosis is unwise to use a limited number of groups of fluoroquinolones, as they are outdated due to low efficiency.
In the future, the researchers hope that the findings will help them in the development of fundamentally new anti-TB drugs.
This is not the first attempt to bring scientific pharmacology to a new level.
Previously, the largest producers of anti-cancer drugs, including GlaxoSmithKline, Amgen and of Celgene, joined the initiative of the Cancer Moonshot 2020 to accelerate the development of new drugs against cancer.